{"id":6555,"date":"2020-10-20T15:44:00","date_gmt":"2020-10-20T20:44:00","guid":{"rendered":"https:\/\/shockwavemedical.com\/clinical-evidence\/disrupt-pad-iii-randomized-clinical-trial\/"},"modified":"2025-07-25T07:39:28","modified_gmt":"2025-07-25T12:39:28","slug":"pad-iii-rct","status":"publish","type":"clinical-evidence","link":"https:\/\/shockwave-jj.l06.project-qa.com\/de\/clinical-evidence\/pad-iii-rct\/","title":{"rendered":"DISRUPT PAD III Randomized Clinical Trial"},"content":{"rendered":"\n<section id=\"block_cb9ed5277d65b74a230fae1b254715d3\" class=\"block block--primary-header u-darkMode u-bgColor_primary\"\n\tstyle=\"--desktop-bg-image: url('https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Background-Pulses.png');\n\t\t\t\t --mobile-bg-image: url('');\">\n\n\t<div class=\"primary-header-container text_colors\">\n\n\t\t<!-- Heading -->\n\t\t<div class=\"heading\">\n\t\t\t<h1 class=\"main-heading\">DISRUPT PAD III Randomized Clinical Trial <\/h1>\n\t\t\t<h3 class=\"sub-heading\">Shockwave intravascular lithotripsy (IVL) provides superior vessel prep and excellent long-term results in calcified vessels while preserving future treatment options. <\/h3>\n\t\t<\/div>\n\n\t\t<!-- Optional links -->\n\t\t\n\t\t<!-- links - J&J -->\n\t\t\n\t\t<!-- Social share -->\n\t\t\t\t<!-- Foreground for Desktop -->\n\t\t\t\t\t<div class=\"desktop-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/DISRUPT-PAD-III-Clinical-Hero-Image-14.png\" alt=\"DISRUPT PAD III RCT logo\" role=\"img\" aria-label=\"Foreground image for desktop\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 955px; --smush-placeholder-aspect-ratio: 955\/970;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t<!-- Foreground for Mobile -->\n\t\t\t\t\t<div class=\"mobile-foreground-file\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Clinical-Hero-Images-mobile-13.png\" alt=\"DISRUPT PAD III Randomized Clinical Trial logo\" role=\"img\" aria-label=\"Foreground image for mobile\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 814px; --smush-placeholder-aspect-ratio: 814\/446;\">\n\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_a06033323eacad4453ad45da758b3ef9\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_7e10e5a89173e852f2d9163221d9e9e3\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<h2><span class=\"TextRun SCXW16247581 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW16247581 BCX0\">DISRUPT<\/span> <span class=\"NormalTextRun SCXW16247581 BCX0\">PAD III: The Largest-ever Randomized Study of Severely Calcified Peripheral Lesions<\/span><\/span><span class=\"EOP SCXW16247581 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/h2>\n\t<\/div>\n\t<\/section>\n\n\n<section id=\"block_a52c5c1d221654906ec23dd79ee38001\" class=\"block block--stat-callout \" role=\"region\" aria-labelledby=\"statCalloutTitle\" aria-describedby=\"statCalloutDesc\">\n\t<h2 id=\"statCalloutTitle\" class=\"sr-only\">Statistics Callout<\/h2> <!-- Add a hidden heading for accessibility -->\n\t<p id=\"statCalloutDesc\" class=\"sr-only\">This section presents key statistical information with numbers and descriptions.<\/p> <!-- Hidden description -->\n\n\t<!-- Changing container to ul for better semantics -->\n\t<ul class=\"container\" role=\"list\">\n\t\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-0\" role=\"listitem\" aria-labelledby=\"block_a52c5c1d221654906ec23dd79ee38001-card-0-number\" aria-describedby=\"block_a52c5c1d221654906ec23dd79ee38001-card-0-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-0-number\">45<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-0-description\">\n\t\t\t\t\t\tGlobal sites\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-1\" role=\"listitem\" aria-labelledby=\"block_a52c5c1d221654906ec23dd79ee38001-card-1-number\" aria-describedby=\"block_a52c5c1d221654906ec23dd79ee38001-card-1-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-1-number\">306<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-1-description\">\n\t\t\t\t\t\tSuperficial femoral artery (SFA)\/popliteal lesions randomized to Shockwave IVL or percutaneous transluminal angioplasty (PTA) \t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-2\" role=\"listitem\" aria-labelledby=\"block_a52c5c1d221654906ec23dd79ee38001-card-2-number\" aria-describedby=\"block_a52c5c1d221654906ec23dd79ee38001-card-2-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-2-number\">83<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span>%<\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-2-description\">\n\t\t\t\t\t\tSevere calcification by Peripheral Academic Research Consortium (PARC), an independent core lab*  \t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t\t<!-- Each card is now an li element for semantic correctness -->\n\t\t\t<li class=\"card\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-3\" role=\"listitem\" aria-labelledby=\"block_a52c5c1d221654906ec23dd79ee38001-card-3-number\" aria-describedby=\"block_a52c5c1d221654906ec23dd79ee38001-card-3-description\">\n\t\t\t\t<div class=\"card-top\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-number\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-3-number\">129 mm<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"card-symbol\">\n\t\t\t\t\t\t\t<span><\/span>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t\t\t<div class=\"card-description font--p\" id=\"block_a52c5c1d221654906ec23dd79ee38001-card-3-description\">\n\t\t\t\t\t\tAverage calcified length by an independent core lab*\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t<\/li>\n\t\t\t\t<\/ul>\n<\/section>\n\n\n<section id=\"block_8c87b5c24337b090973729d0d662ebde\" class=\"block block--wysiwyg wysiwyg_styles u-bgColorNone container\">\n\t<div class=\"u-wysiwyg u-animation\">\n\t\t<p><span class=\"legal_copy\">*Data refers to Shockwave IVL arm of randomized study\u00a0<\/span><\/p>\n\t<\/div>\n\t<\/section>\n\n<section\n\tid=\"block_a06033323eacad4453ad45da758b3ef9\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_57f3104893d2c4afa7f82368785aba40\" class=\"block block--accordion text_colors \">\n\n\t\t<div class=\"accordion__wrapper container\">\n\t\t\n\t\t\t\t\t\t<div class=\"accordion__top u-animation\">\n\t\t\t\t<h2 id=\"accordion-title-block_57f3104893d2c4afa7f82368785aba40\" class=\"sr-only\">Accordion Section<\/h2>\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_57f3104893d2c4afa7f82368785aba40-0\">\n\t\t\t\t\t\t\tSuperior Prep \t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_57f3104893d2c4afa7f82368785aba40-0\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW18985040 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW18985040 BCX0\">Shockwave <\/span><span class=\"NormalTextRun SCXW18985040 BCX0\">IVL\u2019s unique mechanism of action <\/span><span class=\"NormalTextRun SCXW18985040 BCX0\">(MOA) <\/span><span class=\"NormalTextRun SCXW18985040 BCX0\">delivers significantly more luminal gain with lower dilatation pressure and less need for post-dilatation.<\/span><\/span><span class=\"EOP SCXW18985040 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-11077 lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2020\/10\/Superior-Prep-Table-Updated-01-300x128.png\" alt=\"Bar and icon graph illustrating superior procedural success and atraumatic treatment outcomes between Intravascular Lithotripsy (IVL) and Percutaneous Transluminal Angioplasty (PTA). \" width=\"1200\" height=\"511\" data-srcset=\"https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2020\/10\/Superior-Prep-Table-Updated-01-300x128.png 300w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2020\/10\/Superior-Prep-Table-Updated-01-1024x436.png 1024w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2020\/10\/Superior-Prep-Table-Updated-01-768x327.png 768w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2020\/10\/Superior-Prep-Table-Updated-01-1536x654.png 1536w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2020\/10\/Superior-Prep-Table-Updated-01.png 2000w\" data-sizes=\"(max-width: 1200px) 100vw, 1200px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1200px; --smush-placeholder-aspect-ratio: 1200\/511;\" \/><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_57f3104893d2c4afa7f82368785aba40-1\">\n\t\t\t\t\t\t\tPreserved Options \t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_57f3104893d2c4afa7f82368785aba40-1\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW33612559 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW33612559 BCX0\">Shockwave <\/span><span class=\"NormalTextRun SCXW33612559 BCX0\">IVL maintains control of the procedure by minimizing complications such as dissections, <\/span><span class=\"NormalTextRun SCXW33612559 BCX0\">embolization<\/span><span class=\"NormalTextRun SCXW33612559 BCX0\"> and perforations. <\/span><span class=\"NormalTextRun SCXW33612559 BCX0\">Shockwave <\/span><span class=\"NormalTextRun SCXW33612559 BCX0\">IVL significantly reduces the need for bailout stents, preserving future treatment options.<\/span><\/span><span class=\"EOP SCXW33612559 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-6536 lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_2-1024x422.png\" alt=\"Three-part infographic showing the clinical benefits of Intravascular Lithotripsy (IVL) compared to Percutaneous Transluminal Angioplasty (PTA) in terms of reduced dissections, lower complications, and reduced bailout stenting. \" width=\"1200\" height=\"494\" data-srcset=\"https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_2-1024x422.png 1024w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_2-300x124.png 300w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_2-768x316.png 768w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_2-1536x633.png 1536w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_2.png 2000w\" data-sizes=\"(max-width: 1200px) 100vw, 1200px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1200px; --smush-placeholder-aspect-ratio: 1200\/494;\" \/><\/p>\n<p><span class=\"NormalTextRun SCXW66889015 BCX0\"><strong>Embolic protection:<\/strong> Utilized<\/span><span class=\"NormalTextRun SCXW66889015 BCX0\"> in 1.3% of cases in <\/span><span class=\"NormalTextRun SCXW66889015 BCX0\">Shockwave <\/span><span class=\"NormalTextRun SCXW66889015 BCX0\">IVL treatment arm.<\/span><\/p>\n<p><strong>Provisional stent:<\/strong> <span class=\"NormalTextRun SCXW205982432 BCX0\">Utilized<\/span><span class=\"NormalTextRun SCXW205982432 BCX0\"> if residual stenosis \u226550% by visual estimate or unresolved \u2265 type D dissection, and trans-lesional gradient > <\/span><span class=\"NormalTextRun SCXW205982432 BCX0\">10 mm<\/span><span class=\"NormalTextRun SCXW205982432 BCX0\">Hg<\/span><span class=\"NormalTextRun SCXW205982432 BCX0\">.<\/span><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t<div class=\"accordion\" data-layout=\"default_item\">\n\t\t\t\t\t\t<h3 class=\"accordion__trigger toggle__wrapper\">\n\t\t\t\t\t\t<button class=\" btn\" aria-expanded=\"false\" aria-controls=\"accordion-item-block_57f3104893d2c4afa7f82368785aba40-2\">\n\t\t\t\t\t\t\tExcellent Long-Term Results \t\t\t\t\t\t\t<div class=\"accordion-toggle\">\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-chevron-down shockwave\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-plus jj\" aria-hidden=\"true\"><\/i>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\t\t<div id=\"accordion-item-block_57f3104893d2c4afa7f82368785aba40-2\" class=\"accordion__content\">\n\t\t\t\t\t\t\t<div class=\"grid grid--column grid-md--row-reverse\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"grid__col u-wysiwyg wysiwyg_styles\">\n\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW174273412 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW174273412 BCX0\">Shockwave <\/span><span class=\"NormalTextRun SCXW174273412 BCX0\">IVL has <\/span><span class=\"NormalTextRun SCXW174273412 BCX0\">demonstrated<\/span><span class=\"NormalTextRun SCXW174273412 BCX0\"> excellent patency out to two years in a severely calcified patient population.<\/span><\/span><span class=\"EOP SCXW174273412 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter wp-image-6541 lazyload\" data-src=\"https:\/\/shockwavemedical.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_3-1024x519.png\" alt=\"Line graph comparing primary patency rates over 24 months for two treatment groups after an index procedure. \" width=\"1200\" height=\"608\" data-srcset=\"https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_3-1024x519.png 1024w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_3-300x152.png 300w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_3-768x389.png 768w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_3-1536x778.png 1536w, https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/Disrupt_PAD_III_RCT_Global_White_3.png 2000w\" data-sizes=\"(max-width: 1200px) 100vw, 1200px\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" style=\"--smush-placeholder-width: 1200px; --smush-placeholder-aspect-ratio: 1200\/608;\" \/><\/p>\n<h3><span class=\"TextRun SCXW52652993 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW52652993 BCX0\">Number of subjects at risk:<\/span><\/span><span class=\"EOP SCXW52652993 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/h3>\n<table style=\"border-collapse: collapse; width: 100%; height: 48px;\">\n<tbody>\n<tr style=\"height: 24px;\">\n<th style=\"width: 16.6667%; height: 24px; background-color: #eeeeee; border: max(0.0694444vw, 1px) solid #b6bfbf;\"><span class=\"TextRun SCXW208998347 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW208998347 BCX0\">Shockwave <\/span><span class=\"NormalTextRun SCXW208998347 BCX0\">IVL<\/span><\/span><span class=\"EOP SCXW208998347 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/th>\n<td style=\"width: 16.6667%; height: 24px; background-color: #ffffff;\"><strong><span class=\"TextRun SCXW53042425 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW53042425 BCX0\">131<\/span><\/span><span class=\"EOP SCXW53042425 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/strong><\/td>\n<td style=\"width: 16.6667%; height: 24px; background-color: #ffffff;\"><strong>120<\/strong><\/td>\n<td style=\"width: 16.6667%; height: 24px; background-color: #ffffff;\"><strong>107<\/strong><\/td>\n<td style=\"width: 16.6667%; height: 24px; background-color: #ffffff;\"><strong>88<\/strong><\/td>\n<td style=\"width: 16.6667%; height: 24px; background-color: #ffffff;\"><strong>83<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 24px;\">\n<th style=\"width: 16.6667%; height: 24px; background-color: #eeeeee; border: max(0.0694444vw, 1px) solid #b6bfbf;\"><span class=\"TextRun SCXW50867163 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW50867163 BCX0\">PTA<\/span><\/span><span class=\"EOP SCXW50867163 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/th>\n<td style=\"width: 16.6667%; height: 24px;\"><strong>136<\/strong><\/td>\n<td style=\"width: 16.6667%; height: 24px;\"><strong>107<\/strong><\/td>\n<td style=\"width: 16.6667%; height: 24px;\"><strong>95<\/strong><\/td>\n<td style=\"width: 16.6667%; height: 24px;\"><strong>75<\/strong><\/td>\n<td style=\"width: 16.6667%; height: 24px;\"><strong>66<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span class=\"legal_copy\">*Primary patency defined as freedom from provisional stenting at index procedure, freedom from clinically-driven target lesion revascularization, and freedom from restenosis determined by duplex ultrasound.\u00a0<\/span><\/p>\n\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_a06033323eacad4453ad45da758b3ef9\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n\n<section id=\"block_87d683512cb5836168c684aa615034f6\" class=\"block block--youtube-video-with-text-overlay text_colors \">\n\t<div class=\"block__container\">\n\t\t<div class=\"thumbnail\">\n\t\t\t\t\t\t\t<img decoding=\"async\" data-src=\"https:\/\/shockwave-jj.l06.project-qa.com\/wp-content\/uploads\/2024\/11\/youtube-thumbnail-RCT.jpg\" alt=\"Intravascular Lithotripsy for Peripheral Artery Calcification: Disrupt PAD III RCT Mid-Term Outcomes\" src=\"data:image\/svg+xml;base64,PHN2ZyB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==\" class=\"lazyload\" style=\"--smush-placeholder-width: 1280px; --smush-placeholder-aspect-ratio: 1280\/720;\" \/>\n\t\t\t\t\t\t<div class=\"play-button-container\">\n\t\t\t\t<button type=\"button\" aria-label=\"Play video\" class=\"play-button btn\">\n\t\t\t\t\t<i class=\"fa-sharp fa-solid fa-play\" aria-hidden=\"true\"><\/i>\n\t\t\t\t<\/button>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t<!-- Heading, description, and button -->\n\t\t<div class=\"heading-description-button\">\n\t\t\t\t\t\t\t<h2 class=\"heading\">\n\t\t\t\t\tDISRUPT PAD III RCT Mid-Term Outcomes \t\t\t\t<\/h2>\n\t\t\t\n\t\t\t\t\t\t\t<p class=\"description\">\n\t\t\t\t\tWatch Dr. Bill Gray and Dr. Sahil Parikh discuss the significance of the PAD III RCT one- and two-year results. \t\t\t\t<\/p>\n\t\t\t\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<div class=\"video-modal\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"modal-title-block_87d683512cb5836168c684aa615034f6\" style=\"display: none;\">\n\t\t\t\t<button type=\"button\" aria-label=\"Close modal\" class=\"modal-close btn\">\n\t\t\t\t\t<i class=\"fa-sharp fa-regular fa-xmark\" aria-hidden=\"true\"><\/i>\n\t\t\t\t<\/button>\n\t\t\t\t<div class=\"modal-content\">\n\t\t\t\t\t<h2 id=\"modal-title-block_87d683512cb5836168c684aa615034f6\" class=\"sr-only\">Video Player<\/h2>\n\t\t\t\t\t<lite-youtube videoid=\"7p0FsKdRGxs\" style=\"width: 100%; height: 100%;\" title=\"Intravascular Lithotripsy for Peripheral Artery Calcification: Disrupt PAD III RCT Mid-Term Outcomes\"><\/lite-youtube>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/section>\n\n<section\n\tid=\"block_a06033323eacad4453ad45da758b3ef9\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>\n\n<section id=\"block_69e62cde2d04f1527bcb7ed2bdbdd586\" class=\"block block--featured-clinical-evidence \" aria-labelledby=\"featured-clinical-evidence-title\">\n\t\t\t<div class=\"featured-clinical-evidence--top text_colors \">\n\t\t\t<div class=\"featured-clinical-evidence--title\">\n\t\t\t\t\t\t\t\t\t<h2 id=\"featured-clinical-evidence-title\" class=\"heading\">More Shockwave Peripheral IVL Studies <\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-top u--hidden u-md-block\">\n\t\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/de\/clinical-evidence\/\" target=\"_self\" aria-label=\"See All Clinical Evidence - link to page\" rel=\"noopener\">See All Clinical Evidence<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence__btn-wrap featured-clinical-evidence__btn-wrap-bottom u--block u-md-hidden\">\n\t\t\t\t\t\n<a data-atom=\"button\" class=\" btn--secondary\" href=\"https:\/\/shockwavemedical.com\/de\/clinical-evidence\/\" target=\"_self\" aria-label=\"See All Clinical Evidence - link to page\" rel=\"noopener\">See All Clinical Evidence<i aria-hidden=\"true\" class=\"fa-sharp fa-arrow-right fa-light\"><\/i><\/a>\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t<\/div>\n\t\t<ul class=\"featured-clinical-evidence-list text_colors\" role=\"list\">\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6687\" aria-describedby=\"post-category-6687 post-excerpt-6687\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6687\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwave-jj.l06.project-qa.com\/de\/clinical-evidence\/btk-ii\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT BTK II\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6687\">\n\t\t\t\t\t\tGlobal prospective, multi-center, single-arm  study assessing the safety and effectiveness of Shockwave peripheral IVL in treating long, calcified BTK lesions. \t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6687\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6594\" aria-describedby=\"post-category-6594 post-excerpt-6594\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6594\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwave-jj.l06.project-qa.com\/de\/clinical-evidence\/pad-ii\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT PAD II\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6594\">\n\t\t\t\t\t\tCore lab adjudicated, long-term, multi-center study exclusively enrolling heavily calcified lesions building upon DISRUPT PAD I.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6594\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t\t\t\t<li class=\"featured-clinical-evidence-item\" role=\"listitem\" aria-labelledby=\"post-title-6528\" aria-describedby=\"post-category-6528 post-excerpt-6528\">\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--text-container\" id=\"post-title-6528\">\n\t\t\t\t\t\t<a href=\"https:\/\/shockwave-jj.l06.project-qa.com\/de\/clinical-evidence\/pad-iii-os\/\" class=\"featured-clinical-evidence-item--title\">\n\t\t\t\t\t\t\tDISRUPT PAD III Observational Study\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#5B6770\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t\t<div class=\"featured-clinical-evidence-item--arrow-hover\" aria-hidden=\"true\"><svg width=\"25\" height=\"27\" viewBox=\"0 0 25 27\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M3.5 26H21a2.5 2.5 0 002.5-2.5V7.875L16.625 1H6a2.5 2.5 0 00-2.5 2.5v3.75\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><path d=\"M16 1v7.5h7.5M4.75 19.75a3.75 3.75 0 100-7.498 3.75 3.75 0 000 7.498v0zm5 1.25l-1.875-1.875\" stroke=\"#00D2FF\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\/><\/svg><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--excerpt\" id=\"post-excerpt-6528\">\n\t\t\t\t\t\tGlobal prospective, multi-center, single-arm study assessing the safety and effectiveness of Shockwave peripheral IVL in treating long, calcified BTK lesions.\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"featured-clinical-evidence-item--category\" id=\"post-category-6528\">\n\t\t\t\t\t\tPeripheral IVL\t\t\t\t\t<\/div>\n\t\t\t\t<\/li>\n\t\t\t<\/ul>\n<\/section>\n\n\n<section\n\tid=\"block_a06033323eacad4453ad45da758b3ef9\"\n\tclass=\"block block--spacer-with-optional-divider \"\n\taria-label=\"Spacer section with optional divider\">\n\t<div class=\"spacer-with-optional-divider-container container\">\n\n\t\t<!-- Space Above -->\n\t\t<div\n\t\t\tclass=\"space-above\"\n\t\t\tstyle=\"--aboveDesktop: 60px; --aboveMobile: 30px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t\t<!-- Optional Divider -->\n\t\t\n\t\t<!-- Space Below -->\n\t\t<div\n\t\t\tclass=\"space-below\"\n\t\t\tstyle=\"--belowDesktop: 0px; --belowMobile: 0px;\"\n\t\t\taria-hidden=\"true\"\n\t\t\trole=\"presentation\">\n\t\t<\/div>\n\n\t<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>The largest-ever randomized clinical study of Shockwave peripheral IVL treatment in severely calcified peripheral lesions, out to 24 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